Scientific Insights
A multidisciplinary exploration into fasting, mitochondrial function, mtDNA, and the interconnected systems that shape human health.
Trademark Serial Number: 99571183
The Moon Shot
An unconventional question worth exploring.
What if there was one biological signal that could optimize system-wide health with minimal intervention?
As part of developing Harmogenic Intelligence™, founder Gi Gi O’Brien set out to explore just that. This inquiry led to the development of MetaFast®, a Harmogenic mtDNA Fasting Protocol™ exploring how mitochondrial function, energetics, epigenetics, and energy utilization may influence human capacity across interconnected systems.
The Conversation We Are Exploring
The aim is to discuss and spotlight cutting-edge scientific and spiritual insights on chronic states of compromised well-being across interconnected domains of:
Energy & ATP
Inflammation & Immune Function
Cellular Function & Longevity
Mood & Emotional Regulation
Sleep & Recovery
Appetite & Cravings
Metabolism
Cognition
Ultimately, MetaFast® is designed around a larger human objective: increasing the capacity to live, think, create, connect, and contribute; with greater energy, cognitive clarity, emotional and somatic regulation, and sustained capacity for effort and reward.
The Frontier
Exploring one of the most consequential frontiers in human capacity.
At a deeper biological level, this inquiry explores emerging research on mitochondrial dysfunction, inflammation, neurodegeneration, metabolic adaptation, and the biological pathways associated with accelerated aging and chronic disease.
Rather than treating these as isolated conditions, MetaFast® explores how interconnected systems may influence whole-person capacity through the harmonization of biology, behavior, and human flourishing.
Your Invitation
Contributing Expertise
Gi Gi is inviting a small number of professionsals in medicine, health, wellness and spirituality to be interviewed for her upcoming book, The Intelligence of MetaFasting®, and to contribute scientific insights within their own field of expertise.
Current areas of inquiry:
Functional & Integrative Medicine
Ayurveda & Traditional Medicine
Nutrition & Fasting Research
Mitochondrial Biology
Metabolic Physiology
Clinical Medicine
Somatic Therapies
Neurobiology
Epigenetics
Biostatistics
Why This Mission
Gi Gi O’Brien has been researching and practicing fasting for more than 15 years. Her early work in the field began years before MetaFast®, including a manuscript first written in 2020 exploring fasting, biology, neurology, psychology, nutrition, autophagy and related mechanisms.
In 2026, following two Stage IV diagnoses and two major surgeries for Endometriosis then Adenomyosis only four months apart, that longstanding inquiry became an urgent investigation into a question:
What if, instead of only fighting disease, we began understanding the environment in which health thrives?
This question became the catalyst for examining health as an interconnected system, and specifically investigating the relationship between fasting, mitochondrial function, mtDNA, metabolism, the nervous system and human capacity to regulate, heal and thrive.
Please join the exploration. If you are a specialist, we would love to hear from you, and Gi Gi would be delighted to interview you for her upcoming book, The Intelligence of MetaFasting®.
© Copyright Global Intelligence Initiative LLC 2026
2125 Biscayne Blvd
Ste 204 #5977, Miami
Florida 33137 U.S.